Abstract #1925
Labeling of human peripheral blood mononuclear cells with a Fluorine-19 perfluorocarbon agent permits their in vivo detection using cellular MRI and allows for cancer vaccine formulation comparisons
Corby Fink 1,2 , Jeffrey Gaudet 2,3 , Paula Foster 2,3 , and Gregory Dekaban 1,2
1
Microbiology and Immunology, Western
University, London, Ontario, Canada,
2
Robarts
Research Institute, London, ON, Canada,
3
Medical
Biophysics, Western University, London, ON, Canada
A critical aspect of cell-based therapies involving
engineered primary cells is knowledge of the location,
number and persistence of therapeutic cells following
injection. With respect to antigen presenting cell-based
cancer vaccines, tracking and quantification of their in
vivo migration to a secondary lymphoid organ can be used
to not only assess the effectiveness of the vaccine, but
also to compare the effectiveness of different vaccine
formulations. Our laboratory has efficiently labeled
human peripheral blood mononuclear cells with a
Fluorine-19 perfluorocarbon cell-labeling agent, which
permits their in vivo detection and quantification in a
mouse model.
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