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Abstract #1927

MRI detection of brain metastases labeled with iron oxide nanoflowers

Emily Alexandria Waters 1 , Luke Vistain 2 , Liang Mu 3 , Madhavi Puchalapalli 4 , Chad Haney 1 , Basma El Haddad 4 , Brandon Parker 3 , Thomas Meade 5 , and Jennifer Koblinski 4

1 Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, United States, 2 Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, United States, 3 Northwestern University, IL, United States, 4 Pathology, Virginia Commonwealth University, Richmond, VA, United States, 5 Chemistry, Northwestern University, Evanston, IL, United States

Though improved treatment of primary breast cancers has increased patient survival, those diagnosed with brain metastases typically survive only 2-16 months. Understanding mechanisms of breast cancer metastasis to the brain should improve patient outcomes. We modeled metastasis in mice with intracardiac injection of bioluminescent breast cancer cells that had been labeled with iron oxide nanoflowers. We used IVIS to screen for successful cell delivery to the brain and then MRI to track the labeled cells for 7 days after their arrival in the brain.

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