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Abstract #1929

Tracking iron labeled stem cells in bone injury model using MRI

May A Taha 1 , Roman Krawetz 2 , Derrick E Rancourt 2 , John R Matyas 3 , and Jeff F Dunn 1

1 Department of Radiology, Calgary, Alberta, Canada, 2 Department of Biochemistry & Molecular Biology, Alberta, Canada, 3 Department of Comparative Biology and Experimental Medicine, Faculties of Medicine and Veterinary Medicine, University of Calgary, Alberta, Canada

Stem cell therapies show significant promise for stimulating healing of bone injury, but nothing is known of how stem cells migrate after implant. We developed a successful iron labeling protocol for embryonic stem cells. We proved it is possible to track ESCs using 9.4T MRI in a mouse bone injury model and showed that cells migrated to the marrow and to a second injury site. We are the first to image ESC migration in bone injury and, as we did this in mice, it opens the possibility of using the range of mouse models available to study bone injury

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