Non-invasive assessment of hyperthermic ultrasound enhanced tumor drug delivery with CE-MRI

Utilizing mild hyperthermia (40-42C ) has the potential to increase blood flow into tumors, and thus overcome some of the barriers to drug delivery. This study utilizes MRI to determine the effect of ultrasound-induced mild hyperthermia on the uptake of a paramagentically labeled polymer conjugate. The results of this study show that contrast enhancement increased two-fold upon the induction of hyperthermia in the tumor periphery. A five-fold increase in contrast enhancement was also seen in the tumor intersitium. This work suggests that mild hyperthermia has the potential to enhance the therapeutic efficacy of drugs in development for cancer treatment.

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