Abstract #1940
Natural abundance of glycogen and lipids in human calf muscle measured before and after exercise by 13 C MRS at 7T
Eulalia Sers Roig 1 and Rolf Gruetter 1,2
1
Laboratory of Functional and Metabolic
Imaging (LIFMET), Ecole Polytechnique Fdrale de
Lausanne (EPFL), Lausanne, Vaud, Switzerland,
2
Department
of Radiology, Universities of Lausanne and Geneva, Vaud,
Switzerland
Natural abundance 13C MRS allows the detection of a wide
range of 13C signals, such as glycogen in human muscle
at 7T. The energy required for muscular contraction can
be assessed by dynamic 13C MRS while measuring glycogen
and lipid levels before and after exercise. The large
chemical shift dispersion comprising glycogen and lipid
resonances requires uniform 13C-excitation and broadband
1H-decoupling for a reliable assessment of 13C signal
intensities. In this study, changes of glycogen and
lipid levels were monitored in the human calf before and
after exercise by 13C MRS at 7T using uniform
13C-excitation and broadband 1H-decoupling.
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