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Abstract #1940

Natural abundance of glycogen and lipids in human calf muscle measured before and after exercise by 13 C MRS at 7T

Eulalia Sers Roig 1 and Rolf Gruetter 1,2

1 Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, 2 Department of Radiology, Universities of Lausanne and Geneva, Vaud, Switzerland

Natural abundance 13C MRS allows the detection of a wide range of 13C signals, such as glycogen in human muscle at 7T. The energy required for muscular contraction can be assessed by dynamic 13C MRS while measuring glycogen and lipid levels before and after exercise. The large chemical shift dispersion comprising glycogen and lipid resonances requires uniform 13C-excitation and broadband 1H-decoupling for a reliable assessment of 13C signal intensities. In this study, changes of glycogen and lipid levels were monitored in the human calf before and after exercise by 13C MRS at 7T using uniform 13C-excitation and broadband 1H-decoupling.

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