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Abstract #1941

Quantum coherence spectroscopy to measure 1D 1 H-[ 13 C]-lipid signals

Lucas Lindeboom 1,2 , Robin A de Graaf 3 , Christine I Nabuurs 2,4 , Matthijs KC Hesselink 4 , Joachim E Wildberger 2 , Patrick Schrauwen 1 , and Vera B Schrauwen-Hinderling 1,2

1 Department of Human Biology, Maastricht University Medical Center, Maastricht, Netherlands, 2 Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 3 Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT, United States, 4 Department of Human Movement Sciences, Maastricht University Medical Center, Maastricht, Netherlands

13 C-enriched lipid tracers are an excellent candidate for in vivo MRS tracer studies on lipid metabolism. Indirect detection of 13 C-lipid signals can be useful to enhance the detection sensitivity. Single shot methods are preferred in tissue where movement artifacts and/or low fractional enrichments are expected. We here compared the use of modified versions of the conventional ge-HSQC and ge-HMQC to get non phase distorted 1D 1H-[ 13 C]-edited spectra. We show that the ge-HSQC sequence yields the highest signal and is therefore a candidate to be used for studies following the incorporation of 13 C-lipid tracers in human tissue.

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