Abstract #1951
Measuring Glutathione using 1H MR spectroscopy at 3T: MEGA-PRESS vs. STEAM
Felix Raschke 1 , Ralph Noeske 2 , Dorothee P Auer 1 , and Dineen Rob 1
1
Sir Peter Mansfield Imaging Centre, School
of Medicine, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
2
GE
Healthcare, Berlin, Germany MR Application and Workflow
Development, Berlin, Germany
In this study we use 1H MR spectroscopy to investigate
if a conventional short echo STEAM sequence can be used
to measure glutathione in the brains of 14 healthy
controls at 3T. The STEAM results are compared to that
of MEGA-PRESS spectral editing. There is a strong albeit
non-significant correlation between glutathione measured
by MEGA-PRESS and STEAM. Additionally, glutathione
measured in the STEAM sequence shows a low intra- and
inter-subject variability of 5.4% and 10.8% respectively
compared to the inter-subject variability of around 17%
using MEGA-PRESS. Further work is now needed to validate
these initial results.
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