Meeting Banner
Abstract #1951

Measuring Glutathione using 1H MR spectroscopy at 3T: MEGA-PRESS vs. STEAM

Felix Raschke 1 , Ralph Noeske 2 , Dorothee P Auer 1 , and Dineen Rob 1

1 Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 GE Healthcare, Berlin, Germany MR Application and Workflow Development, Berlin, Germany

In this study we use 1H MR spectroscopy to investigate if a conventional short echo STEAM sequence can be used to measure glutathione in the brains of 14 healthy controls at 3T. The STEAM results are compared to that of MEGA-PRESS spectral editing. There is a strong albeit non-significant correlation between glutathione measured by MEGA-PRESS and STEAM. Additionally, glutathione measured in the STEAM sequence shows a low intra- and inter-subject variability of 5.4% and 10.8% respectively compared to the inter-subject variability of around 17% using MEGA-PRESS. Further work is now needed to validate these initial results.

This abstract and the presentation materials are available to members only; a login is required.

Join Here