Glutathione cannot be quantified reliably from short echo PRESS spectra
Faezeh Sanaei Nehzad 1 , Adriana Anton 2 , Bill Deakin 2 , and Stephen Williams 1
Center for Imaging Science, University of
Manchester, Manchseter, United Kingdom,
and Psychiatry Unit, University of Manchester,
Manchester, United Kingdom
Glutathione (GSH) is commonly quantified in the brain
using spectral editing (e.g. MEGA-PRESS), but a number
of studies report GSH measurement using short echo
PRESS. In this study, quantification of GSH using PRESS
and MEGA-PRESS is evaluated at 3T. Two identical
phantoms containing brain metabolites, one with and one
without GSH, were scanned using PRESS and MEGA-PRESS.
Also, seven healthy volunteers were scanned with the
same protocol. The results from PRESS spectra,
quantified with QUEST and from MEGA-PRESS, quantified
with AMARES, were compared. We conclude that GSH cannot
be reliably quantified using short echo PRESS.
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