Abstract #1952
Glutathione cannot be quantified reliably from short echo PRESS spectra
Faezeh Sanaei Nehzad 1 , Adriana Anton 2 , Bill Deakin 2 , and Stephen Williams 1
1
Center for Imaging Science, University of
Manchester, Manchseter, United Kingdom,
2
Neuroscience
and Psychiatry Unit, University of Manchester,
Manchester, United Kingdom
Glutathione (GSH) is commonly quantified in the brain
using spectral editing (e.g. MEGA-PRESS), but a number
of studies report GSH measurement using short echo
PRESS. In this study, quantification of GSH using PRESS
and MEGA-PRESS is evaluated at 3T. Two identical
phantoms containing brain metabolites, one with and one
without GSH, were scanned using PRESS and MEGA-PRESS.
Also, seven healthy volunteers were scanned with the
same protocol. The results from PRESS spectra,
quantified with QUEST and from MEGA-PRESS, quantified
with AMARES, were compared. We conclude that GSH cannot
be reliably quantified using short echo PRESS.
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