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Abstract #1952

Glutathione cannot be quantified reliably from short echo PRESS spectra

Faezeh Sanaei Nehzad 1 , Adriana Anton 2 , Bill Deakin 2 , and Stephen Williams 1

1 Center for Imaging Science, University of Manchester, Manchseter, United Kingdom, 2 Neuroscience and Psychiatry Unit, University of Manchester, Manchester, United Kingdom

Glutathione (GSH) is commonly quantified in the brain using spectral editing (e.g. MEGA-PRESS), but a number of studies report GSH measurement using short echo PRESS. In this study, quantification of GSH using PRESS and MEGA-PRESS is evaluated at 3T. Two identical phantoms containing brain metabolites, one with and one without GSH, were scanned using PRESS and MEGA-PRESS. Also, seven healthy volunteers were scanned with the same protocol. The results from PRESS spectra, quantified with QUEST and from MEGA-PRESS, quantified with AMARES, were compared. We conclude that GSH cannot be reliably quantified using short echo PRESS.

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