Abstract #1953
Measuring GABA using 1H MR spectroscopy at 3T: A comparison of techniques
Felix Raschke 1 , Antonio Napolitano 2 , Ralph Noeske 3 , Dineen Rob 1 , and Dorothee P Auer 1
1
Sir Peter Mansfield Imaging Centre, School
of Medicine, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
2
Enterprise
Risk Management, Unity of Imaging Research, Bambino Ges
Childrens Hospital, Rome, Italy,
3
GE
Healthcare, Berlin, Germany MR Application and Workflow
Development, Berlin, Germany
We compare three MRS sequences to measure GABA at 3T
using 13 healthy controls. The GABA signal of the
popular MEGA-PRESS sequence with TE=68ms correlates with
that of macromolecule suppressed MEGA-PRESS with TE=80ms
and with a previously published optimised PRESS sequence
using a TE and TE1 of 105ms and 15ms respectively. The
PRESS105 may be a suitable sequence to measure GABA
reliably with the benefit of reduced scan time, no
macro-molecule contribution and less susceptibility to
subject motion compared to MEGA-PRESS.
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