Abstract #1954
Glutathione measurement using short-TE 1 H MRS at 3T: accuracy and precision assessment
Lijing Xin 1,2 and Rolf Gruetter 1,3
1
Laboratory for Functional and Metabolic
Imaging (LIFMET), cole polytechnique fdrale de
Lausanne, Lausanne, Vaud, Switzerland,
2
Department
of Psychiatry, Lausanne University Hospital, Lausanne,
Vaud, Switzerland,
3
Department
of Radiology, University of Lausanne and Geneva, Vaud,
Switzerland
This study aims to evaluate the accuracy and precision
of GSH measurements at 3T with short-TE MRS under
various experimental conditions using synthesized
spectra with known metabolite concentrations. An
underestimation of GSH concentrations was observed and
the measurement accuracy was found to depend on the
experimental conditions. The precision of the
measurement is largely influenced by SNR regardless of
the linewidth. We conclude that GSH concentrations can
be measured with high precision using short-TE MRS
methods at 3T when SNR is sufficient. GSH changes can
also be accurately measured if experimental conditions
are carefully matched between groups.
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