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Abstract #1954

Glutathione measurement using short-TE 1 H MRS at 3T: accuracy and precision assessment

Lijing Xin 1,2 and Rolf Gruetter 1,3

1 Laboratory for Functional and Metabolic Imaging (LIFMET), cole polytechnique fdrale de Lausanne, Lausanne, Vaud, Switzerland, 2 Department of Psychiatry, Lausanne University Hospital, Lausanne, Vaud, Switzerland, 3 Department of Radiology, University of Lausanne and Geneva, Vaud, Switzerland

This study aims to evaluate the accuracy and precision of GSH measurements at 3T with short-TE MRS under various experimental conditions using synthesized spectra with known metabolite concentrations. An underestimation of GSH concentrations was observed and the measurement accuracy was found to depend on the experimental conditions. The precision of the measurement is largely influenced by SNR regardless of the linewidth. We conclude that GSH concentrations can be measured with high precision using short-TE MRS methods at 3T when SNR is sufficient. GSH changes can also be accurately measured if experimental conditions are carefully matched between groups.

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