2D Correlated MRS as a quantitative method to asses liver fatty acid composition of ob/ob mouse

Localized Correlation Spectroscopy is used to assess evolution of liver fatty acid in an ob/ob mice model at two time points. A quantitative study is performed using a dedicated time domain quantification procedure using a simplified quantum mechanically basis set. This later is constituted by the sub spin systems involved in the 2D spectrum of triglycerides. Fatty acid Indexes and T2 values are obtained in agreement with expected model evolution.Indexes and T2 values are obtained in agreement with model evolution.

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