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Abstract #1956

Quantification of Individual and Group Uncertainty of Gamma-aminobutyric Acid Concentration in Different Brain Regions Using Residual Bootstrap Analysis

Song Chen 1 , Meng Chen 1 , Congyu Liao 1 , Linfei Wen 1 , Darong Zhu 2 , Xu Yan 3 , Keith Heberlein 4 , and Jianhui Zhong 1

1 Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang, China, 2 Hangzhou First People's Hospital, Hangzhou, Zhejiang, China, 3 MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, 4 Siemens Medical Solutions USA, Inc, Malvern, PA, United States

Gamma-aminobutyric acid (GABA) is one of important inhibitory neurotransmitters, closely related to mental illness such as depression and schizophrenia. MEGA-PRESS, a spectral editing technique in MRS, is a non-invasive method for detecting GABA concentration in vivo. In this study, data from volunteers was acquired using a robust prototype with MEGA-PRESS pulse sequence, and the residual bootstrap analysis was used to assess uncertainty in different regions, variability from repeated scans, and natural variation among different subjects.

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