Abstract #1957
Editing efficiency for macromolecule-suppressed and unsuppressed J-edited GABA spectroscopy
Georg Oeltzschner 1,2 and Pallab K. Bhattacharyya 3,4
1
Department of Diagnostic and Interventional
Radiology, Medical Faculty, University Dusseldorf,
Dsseldorf, Germany,
2
Institute
of Clinical Neuroscience and Medical Psychology, Medical
Faculty, Heinrich-Heine-University Dsseldorf,
Dsseldorf, Germany,
3
Imaging
Institute, Cleveland Clinic, Cleveland, OH, United
States,
4
Cleveland
Clinic Lerner College of Medicine - CWRU, Cleveland, OH,
United States
Editing efficiency (EE) of J-edited GABA spectroscopy is
an important parameter for GABA quantification.
Different methods of calculating EE were applied to
spectra from a GABA phantom, including a macromolecule
(MM) suppressed and a MM unsuppressed editing scheme. It
was found that EE may exceed the expected maximum of 0.5
which can be attributed to the central peak of the 3.01
ppm GABA resonance. Size and shape of the central peak
are shown to differ across editing schemes. Simulation
of J-edited spectra indicate that this effect is driven
by the OFF-resonance spectra, suggesting peak shape and
size are influenced by the set of editing frequencies
and sequence properties.
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