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Abstract #1957

Editing efficiency for macromolecule-suppressed and unsuppressed J-edited GABA spectroscopy

Georg Oeltzschner 1,2 and Pallab K. Bhattacharyya 3,4

1 Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, Dsseldorf, Germany, 2 Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Dsseldorf, Dsseldorf, Germany, 3 Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 4 Cleveland Clinic Lerner College of Medicine - CWRU, Cleveland, OH, United States

Editing efficiency (EE) of J-edited GABA spectroscopy is an important parameter for GABA quantification. Different methods of calculating EE were applied to spectra from a GABA phantom, including a macromolecule (MM) suppressed and a MM unsuppressed editing scheme. It was found that EE may exceed the expected maximum of 0.5 which can be attributed to the central peak of the 3.01 ppm GABA resonance. Size and shape of the central peak are shown to differ across editing schemes. Simulation of J-edited spectra indicate that this effect is driven by the OFF-resonance spectra, suggesting peak shape and size are influenced by the set of editing frequencies and sequence properties.

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