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Abstract #1958

Resolution-enhanced MRS of red bone marrow fat via intermolecular double-quantum coherences in human knees

Jianfeng Bao 1,2 , Yuchuan Zhuang 1 , Yanqin Lin 2 , Zhong Chen 2 , and Jianhui Zhong 1

1 University of Rochester, Rochester, NY, United States, 2 Xiamen University, Xiamen, Fujian, China

Trabecular bone structure leads to serious local inhomogeneous B0 field, rendering it difficult to obtain high resolution fatty acid MRS in red bone marrow. Although intermolecular double-quantum coherences (iDQC) 2D MRS has been shown to overcome macroscopic inhomogeneity induced by biological tissues, this advantage has not been studied in red bone marrow in humans. In this study, a localized module iDQC was used to obtain high resolution fatty acid spectra on red bone marrow in human knee on a 3.0 T human scanner. This technique has potential in providing new biomarker information for diagnosis purposes.

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