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Abstract #1974

Test-retest quantitation of absolute metabolite concentrations with partial volume correction using different segmentation methods

Ahmad Seif Kanaan 1,2 , Andr Pampel 1 , Kirsten Mller-Vahl 2 , and Harald E. Mller 1

1 Nuclear Magnetic Resonance, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Sachsen, Germany, 2 Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School of Hannover, Hannover, Niedersachsen, Germany

The quantitation of absolute metabolite concentrations via Magnetic Resonance Spectroscopy using water as an internal concentration standard, requires the accurate determination of the compartmentation within the localized region of interest. Previous work has shown that different segmentation approaches yield different estimates of metabolite levels in Grey matter [1]. In this study, we investigated the test-retest reliability of absolute metabolite quantitation using two commonly used segmentation algorithms.

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