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Abstract #1979

Mapping stimulus-evoked glutamate and lactate changes in the mouse brain using spectroscopic imaging

Aline Seuwen 1 , Aileen Schrter 1 , and Markus Rudin 1,2

1 Institute for Biomedical Engineering, ETH & University of Zrich, Zrich, Switzerland, 2 Institute for Pharmacology and Toxicology, University of Zrich, Zrich, Switzerland

BOLD fMRI is an indirect readout for neuronal activity, which relies on hemodynamic signal changes. In mice, peripheral stimulation is accompanied by strong changes in cardiovascular parameters eventually confounding specific BOLD response. Non-vascular readouts could constitute an alternative to study stimulus-evoked brain activation. Here we propose to use spectroscopic imaging in mice to visualize more specifically neurotransmitter and metabolite changes associated to neural activation in the respective brain region. Improved spatial and temporal resolution allowed monitoring short term changes occurring when applying e.g. electrical stimuli to the mouse paw.

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