High glutamine C57BL/6 mice
Ivan Tkac 1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States
C57BL/6 is the most widely used mouse strain used in
different research areas including developmental biology
and neuroscience. In addition, C57BL/6 mice are commonly
used as a background strain in the production of
transgenic mouse model of human neurodegenerative
diseases. But these mice exhibit a sporadic congenital
portosystemic shunt resulting in abnormally high levels
of brain glutamine. This study we demonstrate how
MRS can help to identify these mice to eliminate
potential bias in studies using this mouse strain.
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