Meeting Banner
Abstract #1981

In Vivo Longitudinal Measurements Of Brain Energy Metabolism in Chronic Hepatic Encephalopathy in a Rat Model using 31P MRS and 1H MRS

Veronika Rackayova 1 , Bernard Lanz 1 , Corina Berset 2 , Rolf Gruetter 1,2 , Valrie A. McLin 3 , Olivier Braissant 4 , and Cristina Cudalbu 2

1 Laboratory of Functional and Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, 2 Centre d'Imagerie Biomedicale (CIBM), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, 3 Swiss Center for Liver Disease in Children, Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland, 4 Service of Biomedicine, University Hospital of Lausanne, Lausanne, Vaud, Switzerland

1H MRS and 31P MRS were used to study brain (energy) metabolism in Hepatic Encephalopathy (HE) in animal model of Chronic liver disease. We could see 2-fold increase of Gln and decrease in other brain osmolytes but only non-significant decrease in ATP suggesting that mild brain edema, present in HE, is unlikely due to energy disturbances but rather high concentrations of the osmotically active Gln look, for the moment, as one of the principal causes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here