Abstract #1982
Influence of Short-Term Intermittent Ethanol Exposure and Abstinence on Cerebral Neurometabolite Concentrations Determined by Ex vivo 11.7-T Proton Nuclear Magnetic Resonance Spectroscopy
Do-Wan Lee 1,2 , Jung-Whan Min 3 , Jung-Hoon Lee 1,4 , Kyu-Ho Song 1 , and Bo-Young Choe 1
1
Department of Biomedical Engineering, and
Research Institute of Biomedical Engineering, The
Catholic University of Korea College of Medicine, Seoul,
Seoul, Korea,
2
Asan
Institute for Life Sciences, Asan Medical Center, Seoul,
Seoul, Korea,
3
Department
of Radiological Science, The Shingu University College
of Korea, Seongnam, Korea,
4
Department
of Radiology, Kyunghee Medical Center, Seoul, Korea
This study aimed to determine the influence of the
time-dependent effects of SIE exposure on cerebral
neurochemical differences and responses among control
(CNTL) rats and rat groups at 6-h (SIE-06H), 3-days
(SIE-03D), and 7-days (SIE-07D) after the last gavage
procedure, using ex vivo high-resolution spectra. Our
results showed significantly higher Lac, mIns, GSH, and
GABA signals were significantly differed among the CNTL,
SIE-06H, SIE-03D, and SIE-07D. Our results indicate
several potential metabolic markers for time-dependent
influence of short-term intermittent ethanol exposure
and abstinence on frontal cortex.
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