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Abstract #1982

Influence of Short-Term Intermittent Ethanol Exposure and Abstinence on Cerebral Neurometabolite Concentrations Determined by Ex vivo 11.7-T Proton Nuclear Magnetic Resonance Spectroscopy

Do-Wan Lee 1,2 , Jung-Whan Min 3 , Jung-Hoon Lee 1,4 , Kyu-Ho Song 1 , and Bo-Young Choe 1

1 Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Seoul, Korea, 2 Asan Institute for Life Sciences, Asan Medical Center, Seoul, Seoul, Korea, 3 Department of Radiological Science, The Shingu University College of Korea, Seongnam, Korea, 4 Department of Radiology, Kyunghee Medical Center, Seoul, Korea

This study aimed to determine the influence of the time-dependent effects of SIE exposure on cerebral neurochemical differences and responses among control (CNTL) rats and rat groups at 6-h (SIE-06H), 3-days (SIE-03D), and 7-days (SIE-07D) after the last gavage procedure, using ex vivo high-resolution spectra. Our results showed significantly higher Lac, mIns, GSH, and GABA signals were significantly differed among the CNTL, SIE-06H, SIE-03D, and SIE-07D. Our results indicate several potential metabolic markers for time-dependent influence of short-term intermittent ethanol exposure and abstinence on frontal cortex.

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