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Abstract #1983

1H-MRS of Human Pancreas Grafts: Relaxation Times and Metabolite Concentrations

Jan Weis 1 , Lina Carlbom 1 , Lars Johansson 1 , Alireza Biglarnia 2 , Olle Korsgren 3 , and Hkan Ahlstrm 1

1 Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden, 2 Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, 3 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

1H-MRS of human pancreas grafts was performed using a 1.5 T scanner. The aim of the study was estimation of pancreatic water, tCho, and lipid (-CH2-)n relaxation times T1, T2, and absolute concentration of tCho and fat. Spectra were processed by MRUI software package. T1 and T2 values were obtained by mono-exponential fitting of spectral intensities versus repetition or echo times. Knowledge of the relaxation times enables quantification of pancreas metabolite concentrations using water as the internal concentration reference. The pancreatic fat content is useful for evaluation the pancreas graft quality prior to transplantation.

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