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Abstract #1986

Lipid characterization of different organs using HR-MAS NMR spinning speed variation.

Galle Diserens 1 , Christina Precht 2 , Martina Vermathen 3 , Anna Oevermann 4 , Chris Boesch 1 , and Peter Vermathen 1

1 Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, 2 Dept. of Clinical Veterinary Medicine, University Bern, Bern, Switzerland, 3 Dept. of Chemistry & Biochemistry, University Bern, Bern, Switzerland, 4 Dept. of Clinical Research and Veterinary Public Health, University Bern, Bern, Switzerland

Proton HR-MAS NMR can assess mobile lipids from different tissues. The study purpose was to better understand the origin of visible lipids and the cause of this lipid visibility, by investigating the effect of spinning speed variation in HR-MAS NMR I) in different organs, comprising liver, cardiac muscle, breast, kidney and adipose tissue, and II) in white and grey matter accompanied by histological lipid visualization. The spinning speed significantly affects the lipid visibility. Histology results support the hypothesis that lipids from myelinated membranes are NMR-visible at high spinning speed, while lipid droplets may be less affected by the spinning speed.

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