Abstract #1989
Metabolic perturbations of Rat Spleen due to Chronic Cold Stress: 1H NMR based Metabolomic Study
SONIA GANDHI 1 , HEMANTH KUMAR B S 1 , SUNIL KOUNDAL 1 , SHUBHRA CHATURVEDI 2 , RAJENDRA P TRIPATHI 1 , and SUBASH KHUSHU 1
1
NMR Research Centre, INMAS, DELHI, DELHI,
India,
2
Division
and Cyclotron & Radiopharmaceutical Sciences, INMAS,
DELHI, India
The effects of cold stress can be detected in all
aspects of body functioning resulting in multisystem
stress such as cardiovascular and respiratory diseases,
cognitive deficits and neurological changes. Present
study investigates the changes in metabolic profiles of
spleen tissue in rats due to prolonged cold stress using
NMR & multivariate statistical analysis. Results showed
changes in metabolites such as taurine, choline,
creatine, myo-inositol and aspartic acid on cold
exposure up to 15 days indicating osmotic imbalance,
altered reabsorption, changes in cell integrity and
signaling role for cell membrane. Correlation with other
parameters can be helpful in detecting early biomarkers
for cold stress injuries in humans and organ specific
dosimetry.
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