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Abstract #1991

Elevated Levels of Acetate in 1 H NMR of Urine Could Have Diagnostic Utility in Pediatric Urinary Tract Infection

Omkar B Ijare 1 , Tedros Bezabeh 1,2 , Tom Blydt-Hansen 3 , Martin Reed 4 , and Ian C.P. Smith 1

1 Chemistry, University of Winnipeg, Winnipeg, MB, Canada, 2 Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada, 3 Pediatrics, University of British Columbia, Vancouver, BC, Canada, 4 Radiology, University of Manitoba, Winnipeg, MB, Canada

Urinary tract infection (UTI) is the most common bacterial infection in adults (especially women) and children. The majority of UTIs are caused by uropathogenic Escherichia coli (UPEC), accounting for 70 90% of the community acquired UTIs. Due to the longer diagnostic wait time required for the gold standard (the culture method), dipstick methods are commonly used for the quick diagnosis of UTI. Given the high false negative and false positive rates of dipstick methods, other instrumental methods such as 1 H NMR-based metabolic profiling of urine samples have been proposed. This 1 H NMR study on urine samples revealed the presence of elevated levels of acetate in urine samples from pediatric UTI patients compared to the control group.

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