Abstract #1991
Elevated Levels of Acetate in 1 H NMR of Urine Could Have Diagnostic Utility in Pediatric Urinary Tract Infection
Omkar B Ijare 1 , Tedros Bezabeh 1,2 , Tom Blydt-Hansen 3 , Martin Reed 4 , and Ian C.P. Smith 1
1
Chemistry, University of Winnipeg, Winnipeg,
MB, Canada,
2
Human
Nutritional Sciences, University of Manitoba, Winnipeg,
MB, Canada,
3
Pediatrics,
University of British Columbia, Vancouver, BC, Canada,
4
Radiology,
University of Manitoba, Winnipeg, MB, Canada
Urinary tract infection (UTI) is the most common
bacterial infection in adults (especially women) and
children. The majority of UTIs are caused by
uropathogenic Escherichia coli (UPEC), accounting for 70
90% of the community acquired UTIs. Due to the longer
diagnostic wait time required for the gold standard (the
culture method), dipstick methods are commonly used for
the quick diagnosis of UTI. Given the high false
negative and false positive rates of dipstick methods,
other instrumental methods such as
1
H
NMR-based metabolic profiling of urine samples have been
proposed. This
1
H
NMR study on urine samples revealed the presence of
elevated levels of acetate in urine samples from
pediatric UTI patients compared to the control group.
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