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Abstract #1993

High resolution magic angle spinning 1H NMR spectroscopic investigation of listeria brainstem encephalitis in small ruminants: preliminary results

Christina Precht 1 , Galle Diserens 2 , Martina Vermathen 3 , Anna Oevermann 4 , Torsten Seuberlich 4 , Josiane Lauper 1 , Daniela Gorgas 1 , Chris Boesch 2 , and Peter Vermathen 2

1 Dept. of Clinical Veterinary Medicine, University Bern, Bern, Bern, Switzerland, 2 Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, 3 Dept. of Chemistry and Biochemistry, University Bern, Bern, Switzerland, 4 Dept. of Clinical Research and Veterinary Public Health, University Bern, Bern, Switzerland

Listeria brainstem encephalitis is associated with high mortality rates in ruminants and humans. The purpose of our study was to investigate metabolic changes in diseased small ruminants as a model for an inflammatory disease. HR-MAS NMR spectroscopy identified clear differences in the metabolic profile of biopsies from the primarily affected brainstem. In the thalamus, which commonly did show no or mild inflammatory infiltrates, no clear separation but a trend towards a clustering of the control and diseased group could be observed, and may indicate that NMR spectroscopy is able to detect metabolic changes before histopathologically observable inflammatory infiltrates occur.

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