Abstract #1994
Metabonomics study of urine in patients with Celiac disease using in-vitro proton MR Spectroscopy
Naranamangalam R Jagannathan 1 , Deepti Upadhyay 1 , Uma Sharma 1 , Prasenjit Das 2 , Siddharth Dutta Gupta 2 , and Govind K Makharia 3
1
Department of NMR and MRI Facility, All
India Institute of Medical Sciences, New Delhi, Delhi,
India,
2
Department
of Pathology, All India Institute of Medical Sciences,
New Delhi, Delhi, India,
3
Department
of Gastroenterology & Human Nutrition, All India
Institute of Medical Sciences, New Delhi, Delhi, India
Celiac disease (CeD) is an autoimmune enteropathy caused
by ingestion of gluten and related prolamines present in
cereals like wheat, rye, and barley in genetically
predisposed individuals. Proton NMR based metabolomics
of urine of CeD patients showed higher concentration of
trans-aconitate suggesting the alteration in energy
metabolism. Urine of CeD patients were also
characterized by higher level of fucose. This may be due
to the liver abnormalities associated with CeD.The
findings of the present study suggested the utility of
NMR based metabonomics in determining the biomarker/s
for the differentiation of CeD from controls.
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