Sodium (23Na) and UTE MRI for Detection of Nerve Cell Injuries in Concussed Patients: Preliminary Study

This work presents a preliminary study of a novel methodology for noninvasive detection of membrane disruption of nerve cells (neurons) and stretching tears of nerve fibers (axons) in concussed patients. Sodium (23Na) MRI was used to detect cell membrane disruption through the change of intracellular sodium concentration while high resolution (HR) ultrashort echo time (UTE) proton (1H) MRI was used to detect axonal tears through thin fissuring or tearing in brain tissues. Both imaging modalities were performed on a clinical scanner at 3T. The results showed promise of the proposed method for the detection of nerve cell injuries in concussed patients.

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