Abstract #1997
Assessing water influx and retention in the brain of AQP4 knockout mice by 17 O-MRI
Yifan Zhang 1 , Bernadette O Erokwu 2 , Yuchi Liu 1 , George W Farr 3,4 , Walter F Boron 4 , Chris A Flask 5,6 , and Xin Yu 4,5
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States,
2
Radiology,
Case Western Reserve University, Cleveland, OH, United
States,
3
Aeromics,
LLC, Cleveland, OH, United States,
4
Physiology
and Biophysics, Case Western Reserve University,
Cleveland, OH, United States,
5
Biomedical
Engineering and Radiology, Case Western Reserve
University, Cleveland, OH, United States,
6
Pediatrics,
Case Western Reserve University, Cleveland, OH, United
States
In this study, oxygen-17 chemical shift imaging (
17
O-CSI)
was combined with a keyhole acquisition strategy to
delineate the kinetics of H
2
17
O
uptake and washout in mouse brains with high temporal
resolution. The utility of the method was evaluated in a
study comparing H
2
17
O uptake and
retention in the brains of AQP4-knockout (AQP4-KO) and
wildtype mice. The results showed that AQP4-KO led to
decreased H
2
17
O uptake and
retention but an unaltered rate of H
2
17
O
washout.
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