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Abstract #1996

B 0 insensitive biexponentially weighted 23 Na imaging

Nadia Benkhedah 1 and Armin M. Nagel 1

1 Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

The intracellular sodium concentration is of great interest since it is a potential measure for small changes of the sodium ion homeostasis. Methods which allow a weighting toward intracellular sodium are based on the generation a weighted subtraction image and are thus highly influenced by inhomogeneities of the magnetic field. In the two pulse sequence two different pathways contribute to the long echo time image, so destructive interference can also lead to signal voids in regions prone to field inhomogeneities. In this study, the pathways of the two pulse sequence have been acquired separately to obtain an intracellular weighted 23 Na image which is more robust to variations in the main magnetic field.

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