Meeting Banner
Abstract #2000

In vivo Chloride Quantification with Partial Volume Corrected 35 Cl-MRI

Sebastian C. Niesporek 1 , Aaron S. Kujawa 1 , Nadia Benkhedah 1 , and Armin M. Nagel 1

1 Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Chloride regulates fundamental physiological processes which makes quantitative ( 35 Cl)-MRI interesting for biomedical research applications. Partial volume effects caused by larger voxel sizes due to a much lower MR-sensitivity and fast relaxation times strongly reduce the accuracy of concentration measurements. In this work partial volume correction was applied on 35 Cl-data of phantom and in vivo measurements. Quantification was performed using an external reference cushion as well as B 0 - and B 1 -correction. Good correction capability was seen for phantom measurements and in vivo application allowed quantification of chlorine tissue concentration in the human brain (CSF: 99 plus-or-minus sign 8, brain matter: 27 plus-or-minus sign 3).

This abstract and the presentation materials are available to members only; a login is required.

Join Here