In vivo Chloride Quantification with Partial Volume Corrected 35 Cl-MRI

Chloride regulates fundamental physiological processes which makes quantitative ( ³⁵ Cl)-MRI interesting for biomedical research applications. Partial volume effects caused by larger voxel sizes due to a much lower MR-sensitivity and fast relaxation times strongly reduce the accuracy of concentration measurements. In this work partial volume correction was applied on ³⁵ Cl-data of phantom and in vivo measurements. Quantification was performed using an external reference cushion as well as B ₀ - and B ₁ -correction. Good correction capability was seen for phantom measurements and in vivo application allowed quantification of chlorine tissue concentration in the human brain (CSF: 99 8, brain matter: 27 3).

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