Abstract #2003
Quantitative evaluation of the first order rate constant of creatine-kinase reaction in ovine heart using Magnetization Transfer 31 P Magnetic Resonance Spectroscopy (MT- 31 P-MRS)
Bijaya Thapa 1 , Marjanna Dahl 2 , Deborah Frank 2 , Phillip Burch 3 , and Eun-Kee Jeong 1,4
1
Dept. of Physics and Astronomy, Utah Center
for Advanced Imaging Research, University of Utah, Salt
Lake City, Utah, United States,
2
Dept.
of Pediatrics, University of Utah, Utah, United States,
3
Dept.
of Surgery, University of Utah, Utah, United States,
4
Dept.
of Radiology, Korea University, Seoul, Korea
Oxandrolone is supposed to improve cardiac energy
utilization in the infants with hypoplastic left heart
syndrome (HPLS). HPLS infants have high mortality and
are unable to gain weight may be due to high energy
requirement from their shunt dependent physiology.We
evaluate creatine kinase (CK) rate of the heart of the
HLHS modeled lamb using 31P-MT-MRS. For this we
developed a 1H/31P double tuned coil, TR switch and
1D-MT-CSI pulse sequence.The hardware were optimized for
the 31P signal. Our initial studies shows an increase in
the CK rate of oxandrolone-treated shunted heart
compared to shunted heart.
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