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Abstract #2003

Quantitative evaluation of the first order rate constant of creatine-kinase reaction in ovine heart using Magnetization Transfer 31 P Magnetic Resonance Spectroscopy (MT- 31 P-MRS)

Bijaya Thapa 1 , Marjanna Dahl 2 , Deborah Frank 2 , Phillip Burch 3 , and Eun-Kee Jeong 1,4

1 Dept. of Physics and Astronomy, Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, United States, 2 Dept. of Pediatrics, University of Utah, Utah, United States, 3 Dept. of Surgery, University of Utah, Utah, United States, 4 Dept. of Radiology, Korea University, Seoul, Korea

Oxandrolone is supposed to improve cardiac energy utilization in the infants with hypoplastic left heart syndrome (HPLS). HPLS infants have high mortality and are unable to gain weight may be due to high energy requirement from their shunt dependent physiology.We evaluate creatine kinase (CK) rate of the heart of the HLHS modeled lamb using 31P-MT-MRS. For this we developed a 1H/31P double tuned coil, TR switch and 1D-MT-CSI pulse sequence.The hardware were optimized for the 31P signal. Our initial studies shows an increase in the CK rate of oxandrolone-treated shunted heart compared to shunted heart.

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