Abstract #2002
Reduced NAA and Glutamate in Healthy Military Subjects Compared to Civilian Controls
Huijun Liao 1 , Kristin Heaton 2 , Praveen Merugumala 1 , Jessica Saurman 2 , Xi Long 1 , Irina Orlovsky 2 , Sai Merugumala 1 , Kelly Rudolph 2 , Nicole Murphy 2 , Benjamin Rowland 1 , and Alexander P. Lin 1
1
Center for Clinical Spectroscopy, Brigham
and Women's Hospital, Boston, MA, United States,
2
Military
Performance Division, US Army Research Institute of
Environmental Medicine, Natick, MA, United States
The objective of this H MRS study was to investigate
whether healthy age and gendered-matched civilian
subjects and military subjects show significant
differences in MRS quantifiable metabolites. Compared to
the healthy civilian group, lower Glu and NAA were found
in the healthy military group across four voxels and
were significant in posterior cingulate gyrus and
parietal white matter. These findings could not be
explained by differences in neurocognitive test
performance or education levels which did not
significantly differ between the two groups. Our results
demonstrate the importance of utilizing appropriate
military controls for military studies.
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