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Abstract #2005

Detection of GABA Concentration in ACC and OCC by MEGA-PRESS

Darong Zhu 1 , Song Chen 2 , Xu Yan 3 , Linfei Wen 2 , Congyu Liao 2 , Meng Chen 2 , Keith Heberlein 4 , and Jianhui Zhong 2

1 Hangzhou First People's Hospital, Hangzhou, Zhejiang, China, 2 Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang, China, 3 MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, 4 Siemens Medical Solutions USA, Inc, Malvern, PA, United States

Glutamate (Glu) and gamma-aminobutyric acid (GABA) are very important neurotransmitters, and they play critical roles in mental illness such as depression and schizophrenia. However, neurological bases and mechanisms of GABA for quantifying specific diseases or characterizing regional neural function remain poorly understood. Metabolites such as GABA are difficult to be detected owing to their lower concentration and J-coupling effect. MEGA-PRESS, a sequence based on J-difference spectral editing, can detect the regional variations of GABA concentration, which will be useful in investigating the concentration of GABA in different brain regions and its correlation with the function of the nervous system.

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