Abstract #2005
Detection of GABA Concentration in ACC and OCC by MEGA-PRESS
Darong Zhu 1 , Song Chen 2 , Xu Yan 3 , Linfei Wen 2 , Congyu Liao 2 , Meng Chen 2 , Keith Heberlein 4 , and Jianhui Zhong 2
1
Hangzhou First People's Hospital, Hangzhou,
Zhejiang, China,
2
Center
for Brain Imaging Science and Technology, Department of
Biomedical Engineering, Zhejiang University, Hangzhou,
Zhejiang, China,
3
MR
Collaboration NE Asia, Siemens Healthcare, Shanghai,
China,
4
Siemens
Medical Solutions USA, Inc, Malvern, PA, United States
Glutamate (Glu) and gamma-aminobutyric acid (GABA) are
very important neurotransmitters, and they play critical
roles in mental illness such as depression and
schizophrenia. However, neurological bases and
mechanisms of GABA for quantifying specific diseases or
characterizing regional neural function remain poorly
understood. Metabolites such as GABA are difficult to be
detected owing to their lower concentration and
J-coupling effect. MEGA-PRESS, a sequence based on
J-difference spectral editing, can detect the regional
variations of GABA concentration, which will be useful
in investigating the concentration of GABA in different
brain regions and its correlation with the function of
the nervous system.
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