Abstract #2006
Evaluation of glutamatergic metabolism and its role in neurovascular coupling by combined proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in aging
Pui Wai Chiu 1 , Peiying Liu 2 , Queenie Chan 3 , Raymond Chuen Chung Chang 4 , Leung Wing Chu 5 , Hanzhang Lu 2 , and Henry Ka Fung Mak 1
1
Diagnostic Radiology, The University of Hong
Kong, Hong Kong, Hong Kong, Hong Kong,
2
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Texas, United States,
3
Philips
Healthcare, Hong Kong, Hong Kong,
4
Laboratory
of Neurodegenerative Disease, Department of Anatomy, The
University of Hong Kong, Hong Kong, Hong Kong,
5
Division
of Geriatric Medicine, Department of Medicine, Queen
Mary Hospital, Hong Kong, Hong Kong
In this study, we evaluated the age-related change in
glutamatergic metabolism and its role in neurovascular
coupling via quantitiave proton magnetic resonance
spectroscopy and pseudo-continuous arterial spin
labeling in anterior cingulate cortex (ACC). Glutamine
concentration was found to increase with age, whereas as
both global and regional cerebral blood flow (CBF) in
ACC showed age-related decline. However, no direct
relationship was found between CBF and glutamatergic
synaptic activity in aging suggesting the age-related
alteration in glutamatergic metabolism might not
directly affect CBF.
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