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Abstract #2007

Multi-Voxel Imaging of GABA Temporal Dynamics: A Double-blind Drug-Challenge Crossover Study at 4 Tesla

John Jensen 1,2 , Stephanie Licata 1,2 , Lisa Nickerson 1,2 , Marisa Silveri 1,2 , Carolyn Caine 2 , Kristina Wang 2 , Rosemond Villefuerte 2 , Kevin Hill 1,2 , and David Olson 1,2

1 Harvard Medical School, Boston, MA, United States, 2 McLean Hospital, Belmont, MA, United States

Multi-voxel imaging of pharmaco-dynamic changes in GABA is possible by combining MRSI with the well-known MEGAPRESS-based difference-editing acquisition. Our functional MRSI (fMRSI) technique is demonstrated during a double-blind crossover design drug challenge study of placebo, stimulant and sedative drug effects. We image brain GABA levels, both spatially and temporally, in order to assess the effects of sedatives and stimulants on brain GABA over time. Refinements of this methodology should place fMRSI in the same functional realm of other functional imaging modalities, e.g., positron-emission tomography (PET) with while being completely non-invasive.

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