Multi-Voxel Imaging of GABA Temporal Dynamics: A Double-blind Drug-Challenge Crossover Study at 4 Tesla
John Jensen 1,2 , Stephanie Licata 1,2 , Lisa Nickerson 1,2 , Marisa Silveri 1,2 , Carolyn Caine 2 , Kristina Wang 2 , Rosemond Villefuerte 2 , Kevin Hill 1,2 , and David Olson 1,2
Harvard Medical School, Boston, MA, United
Hospital, Belmont, MA, United States
Multi-voxel imaging of pharmaco-dynamic changes in GABA
is possible by combining MRSI with the well-known
MEGAPRESS-based difference-editing acquisition. Our
functional MRSI (fMRSI) technique is demonstrated
during a double-blind crossover design drug challenge
study of placebo, stimulant and sedative drug effects.
We image brain GABA levels, both spatially and
temporally, in order to assess the effects of sedatives
and stimulants on brain GABA over time. Refinements of
this methodology should place fMRSI in the same
functional realm of other functional imaging modalities,
e.g., positron-emission tomography (PET) with while
being completely non-invasive.
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