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Abstract #2016

Lipid and macromolecule suppression by double inversion recovery in metabolic mapping of the brain at 7T

Gilbert Hangel 1 , Bernhard Strasser 1 , Michal Povaan 1 , Stephan Gruber 1 , Marek Chmelik 1 , Siegfried Trattnig 1 , and Wolfgang Bogner 1

1 MCRE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Vienna, Austria

This work presents a method of lipid and macromolecule suppression using double inversion recovery (DIR) for accelerated FID MRSI in the brain at 7T. DIR suppression greatly reduces artifacts caused by extracranial lipids and macromolecules, caused by fold-in due to parallel imaging and non-optimal PSF. Two 10th-order WURST pulses with 80 ms pulse duration and their timing were optimized for 7T with a TI1/TI2 of 160/75 ms and a total TR of 760 ms. Loss of metabolite SNR was quantified in phantom measurements while volunteer measurements showed in vivo feasibility and successful lipid artifact reduction.

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