High resolution 1H MRSI without lipid suppression at short echo times using variable density spirals

The leakage of extra cranial lipids to the brain and unsuppressed water is one of the biggest obstacles in acquiring reliable metabolite estimates in MR spectroscopic imaging (MRSI). Current methods to suppress lipids require either considerable expertise, provides only partial brain coverage, or result in loss of metabolite SNR. We introduce a variable density spiral sequence to considerably improve k-space coverage with minimal loss in metabolite SNR. A two step recovery strategy is used to suppress the nuisance signals and obtain good quality short echo-time MRSI spectra without any fat suppression methods.

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