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Abstract #2022

Regional alterations between different anaesthesia protocols effects on the mice brain using resting-state fMRI

Tong Wu 1 , Joanes Grandjean 2 , Simone C. Bosshard 3 , Markus Rudin 2 , David Reutens 3 , and Tianzi Jiang 1,4

1 Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia, 2 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 3 The Centre for Advanced Imaging, The University of Queensland, Queensland, Australia, 4 Brainnetome Centre, Institute of Automation, Chinese Academy of Sciences, Beijing, China

Anesthesia is an integral part of most resting-state fMRI mice studies and does not influence the brain as a whole to the same degree. This study attempts to examine intra-regional alterations in spontaneous fMRI signals induced by different anaesthesia protocols. Regional homogeneity (ReHo) is a measure of the temporal similarity of a local voxel neighborhood. We observed that medetomidine showed increased ReHo in striatum and decreased ReHo in the cortex and thalamus compared to other agents. Urethane showed increased ReHo in thalamus compared to several other agents. Global signal regression did not introduce dramatic changes to ReHo in this study.

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