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Abstract #2029

Contributions of spiking activity to the fMRI response in the rat olfactory bulb

Alexander John Poplawsky 1 , Mitsuhiro Fukuda 1 , and Seong-Gi Kim 2,3

1 Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, 3 Biomedical Engineering and Biological Sciences, Sungkyunkwan University (SKKU), Suwon, Korea

The contribution of neural spiking activity to the fMRI response is not completely understood. In the current study, we directly suppressed the spiking of output neurons in the rat olfactory bulb by simultaneous stimulation of excitatory and inhibitory neural pathways and measured the resultant cerebral blood volume-weighted (CBV) fMRI changes. We found a small, but significant, CBV increase due to spiking activity, while the majority of the increase corresponded to an inseparable combination of synaptic and spiking activities. We conclude that, although synaptic activity may be the dominant source of the fMRI response, spiking activity does contribute slightly.

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