Abstract #2029
Contributions of spiking activity to the fMRI response in the rat olfactory bulb
Alexander John Poplawsky 1 , Mitsuhiro Fukuda 1 , and Seong-Gi Kim 2,3
1
Radiology, University of Pittsburgh,
Pittsburgh, Pennsylvania, United States,
2
Center
for Neuroscience Imaging Research, Institute for Basic
Science (IBS), Suwon, Korea,
3
Biomedical
Engineering and Biological Sciences, Sungkyunkwan
University (SKKU), Suwon, Korea
The contribution of neural spiking activity to the fMRI
response is not completely understood. In the current
study, we directly suppressed the spiking of output
neurons in the rat olfactory bulb by simultaneous
stimulation of excitatory and inhibitory neural pathways
and measured the resultant cerebral blood
volume-weighted (CBV) fMRI changes. We found a small,
but significant, CBV increase due to spiking activity,
while the majority of the increase corresponded to an
inseparable combination of synaptic and spiking
activities. We conclude that, although synaptic activity
may be the dominant source of the fMRI response, spiking
activity does contribute slightly.
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