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Abstract #2030

Near-Physiological Mouse fMRI of Nociception

Henning Matthias Reimann 1 , Jaroslav Marek 1 , Jan Hentschel 1 , Till Huelnhagen 1 , Andreas Pohlmann 1 , and Thoralf Niendorf 1,2

1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Berlin, Germany, 2 Experimental and Clinical Research Center, Charite-Universitatsmedizin, Berlin, Germany

Chronic pain is still a major clinical issue with limited treatment options. The combination of fMRI and mouse genetics provides great potential for novel targeted drug development. Still, the potential of nociceptive mouse studies using fMRI is as yet untapped due to methodological constraints. Here we present enabling methodology, which allows near-physiological nociceptive mouse fMRI studies yielding spatially discrete BOLD effects of high magnitude for mild noxious stimuli of 46C. This is the first report on BOLD activation patterns or BOLD effects of this significance and magnitude in mouse fMRI with thermostimulation.

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