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Abstract #2031

Determination of sources for evoked BOLD response under Hyperbaric Oxygen

Damon Philip Cardenas 1,2 , Eric R Muir 1,3 , Shiliang Huang 3 , and Timothy Q Duong 1,3

1 University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 2 Biomedical Engineering, University of Texas San Antonio, San Antonio, Texas, United States, 3 Research Imaging Institute, San Antonio, Texas, United States

Hyperbaric oxygen (HBO) therapy is used to treat a number of ailments. Previously, during HBO at 3 atmospheres absolute fMRI studies, it was observed that BOLD response to an evoked stimulus was not washed out as a result of highly increased oxygen concentration. Additional experiments were performed to evaluate the potential contributions of stimulus-evoked inflow, spin density, and electrical activity to BOLD fMRI responses under HBO. CBF and BOLD fMRI of forepaw stimulation in anesthetized rats was performed under HBO and compared with normobaric air .

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