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Abstract #2040

BOLD-signal representation of incisional and inflammatory pain in rat brain after noxious electrical and noxious mechanical stimulation

Saeedeh Amirmohseni 1 , Daniel Segelcke 2 , Esther Pogatzki-Zahn 2 , and Cornelius Faber 1

1 Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany, 2 Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Muenster, Germany

The present study investigates the BOLD-response in pain-related brain regions in an incisional and an inflammatory rat model during noxious electrical stimulation (NES) and noxious mechanical stimulation (NMS) of the injured hindpaw under the anesthesia with medetomidine. Differences in the response to NMS and NES were observed. Upon NMS, the response in the inflammation group was higher as compared to both incision and sham group. Upon NES, significantly higher responses were observed for both pain models as compared with the sham group. Different responses for the two pain models were observed in S1 and RSC.

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