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Abstract #2041

Identify the single unit of neurovascular coupling by single-vessel fMRI and optogenetics

Maosen Wang 1,2 , Yi He 1 , Yaohui Tang 1 , Hellmut Merkle 3 , and Xin Yu 1,2

1 Research Group of Translational Neuroimaging and Neural Conteol,High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany, 2 Graduate School of Neural & Behavioural Sciences International Max Planck Research School, University of Tuebingen, Tuebingen, Baden-Wuerttemberg, Germany, 3 Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Str, National Institutes of Health, Bethesda, MD, United States

It has been demonstrated that the hemodynamic signal from individual venules can be detected directly with fMRI. Here, the hemodynamic signal from BOLD and CBV fMRI was measured at high temporal(100ms) and spatial resolution(150x150m) in layer 4/5 of the rat forepaw S1with fast gradient-echo MRI. Distinctly different voxels were activated in BOLD vs CBV fMRI. In contrast to the BOLD activated voxels primarily located at the penetrating venules, CBV activated voxels were primarily located at penetrating arterioles. This result makes it possible to directly image the CBV and BOLD response at the single-vessel level to understand neurovascular coupling.

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