Abstract #2041
Identify the single unit of neurovascular coupling by single-vessel fMRI and optogenetics
Maosen Wang 1,2 , Yi He 1 , Yaohui Tang 1 , Hellmut Merkle 3 , and Xin Yu 1,2
1
Research Group of Translational Neuroimaging
and Neural Conteol,High Field Magnetic Resonance, Max
Planck Institute for Biological Cybernetics, Tuebingen,
Baden-Wuerttemberg, Germany,
2
Graduate
School of Neural & Behavioural Sciences International
Max Planck Research School, University of Tuebingen,
Tuebingen, Baden-Wuerttemberg, Germany,
3
Laboratory
of Functional and Molecular Imaging, National Institute
of Neurological Disorders and Str, National Institutes
of Health, Bethesda, MD, United States
It has been demonstrated that the hemodynamic signal
from individual venules can be detected directly with
fMRI. Here, the hemodynamic signal from BOLD and CBV
fMRI was measured at high temporal(100ms) and spatial
resolution(150x150m) in layer 4/5 of the rat forepaw
S1with fast gradient-echo MRI. Distinctly different
voxels were activated in BOLD vs CBV fMRI. In contrast
to the BOLD activated voxels primarily located at the
penetrating venules, CBV activated voxels were primarily
located at penetrating arterioles. This result makes it
possible to directly image the CBV and BOLD response at
the single-vessel level to understand neurovascular
coupling.
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