Abstract #2043
Impact of Anesthesia on Optogenetically Activated Medical Prefrontal Functional Network in Rats
Zhifeng Liang 1,2 , Glenn D.R. Waston 2,3 , Kevin D. Alloway 2,3 , Gangchea Lee 1 , Thomas Neuberger 1 , and Nanyin Zhang 1,2
1
Dept. of Biomedical Engineering,
Pennsylvania State University, University Park, PA,
United States,
2
Center
for Neural Engineering, The Huck Institutes of Life
Sciences, Pennsylvania State University, University
Park, PA, United States,
3
Neural
and Behavioral Sciences, College of Medicine,
Pennsylvania State University, Hershey, PA, United
States
It has been increasingly recognized that anesthesia has
profound impacts on functional magnetic resonance
imaging (fRMI) studies. Specifically, we have previously
demonstrated the impact of anesthesia on global
organization and local circuits in rodents using
resting-state functional MRI (rs-fMRI). To further
explore this impact in tas- based fMRI, we utilized
optogenetics-fMRI (opto-fMRI) to examine the global
impact of optically induced neural activation of
infralimbic cortex in rodents. The results indicated
that both the spatial extent and the amplitude of BOLD
signal activation were reduced in the anesthetized
state, compare to the awake state.
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