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Abstract #2043

Impact of Anesthesia on Optogenetically Activated Medical Prefrontal Functional Network in Rats

Zhifeng Liang 1,2 , Glenn D.R. Waston 2,3 , Kevin D. Alloway 2,3 , Gangchea Lee 1 , Thomas Neuberger 1 , and Nanyin Zhang 1,2

1 Dept. of Biomedical Engineering, Pennsylvania State University, University Park, PA, United States, 2 Center for Neural Engineering, The Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, United States, 3 Neural and Behavioral Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, United States

It has been increasingly recognized that anesthesia has profound impacts on functional magnetic resonance imaging (fRMI) studies. Specifically, we have previously demonstrated the impact of anesthesia on global organization and local circuits in rodents using resting-state functional MRI (rs-fMRI). To further explore this impact in tas- based fMRI, we utilized optogenetics-fMRI (opto-fMRI) to examine the global impact of optically induced neural activation of infralimbic cortex in rodents. The results indicated that both the spatial extent and the amplitude of BOLD signal activation were reduced in the anesthetized state, compare to the awake state.

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