Abstract #2065
Improvement of task-based and resting-state fMRI using GRAPPA accelerated EPI with a FLASH based reference scan
Siyuan Liu 1 , Lalith Talagala 2 , Souheil Inati 3 , Yisheng Xu 1 , Ho Ming Chow 1 , Gang Chen 4 , and Allen Braun 1
1
NIDCD, National Institutes of Health,
Bethesda, Maryland, United States,
2
NMRF/NINDS,
National Institutes of Health, Bethesda, MD, United
States,
3
FMRIF/NIMH,
National Institutes of Health, Bethesda, MD, United
States,
4
SSCC/NIMH,
National Institutes of Health, Bethesda, MD, United
States
GRAPPA parallel acquisition technique (PAT) is
frequently used in current fMRI EPI protocols to reduce
EPI distortions and to increase the time resolution.
Here, we demonstrated that when FLASH rather than EPI
based reference scans were used in GRAPPA accelerated
EPI, the sensitivity to detect brain activations
increased in task-related fMRI and such an increase
could be critical in detecting activated regions with
small effect sizes at the group level. Using FLASH
reference scans also improved the group-level
resting-state functional connectivity results. All
improvements are attributed to the enhancement of
temporal SNR when using FLASH based reference scans.
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