Abstract #2066
Novel heterogeneity analysis of resting-state fluctuations in first-fit seizures and new-onset epilepsy
Lalit Gupta 1 , Marille Vlooswijk 2 , Rob P. W. Rouhl 2 , Rick Janssens 2 , Anton de Louw 3 , Bert Aldenkamp 3 , Shrutin Ulman 1 , Ren M.H. Besseling 4 , Paul A.M. Hofman 2 , Jacobus F. A. Jansen 4 , and Walter H Backes 4
1
Philips India Ltd., Bangalore, Karnataka,
India,
2
Dept
of Neurology, Maastricht University Medical Center,
Maastricht, Netherlands,
3
Epilepsy
Center Kempenhaeghe, Heeze, Netherlands,
4
Department
of Radiology, Maastricht University Medical Center,
Maastricht, Netherlands
Temporal heterogeneity in BOLD time-series in patients
with a suspect of a single epileptic seizure (first-fit)
has been compared to patients with new-onset epilepsy
and healthy controls. Known temporal heterogeneity
measures, including fractional amplitude of low
frequency fluctuations and regional homogeneity, were
used for time-series analysis. Results suggest that
particularly for the low frequency range, 0.02-0.09 Hz,
first-fit patients show decreased amplitude of the BOLD
fluctuations. These effects show that the analysis of
frequency fluctuations has potential to predict which
patients are at increased risk to develop epilepsy after
a single seizure.
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