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Abstract #2066

Novel heterogeneity analysis of resting-state fluctuations in first-fit seizures and new-onset epilepsy

Lalit Gupta 1 , Marille Vlooswijk 2 , Rob P. W. Rouhl 2 , Rick Janssens 2 , Anton de Louw 3 , Bert Aldenkamp 3 , Shrutin Ulman 1 , Ren M.H. Besseling 4 , Paul A.M. Hofman 2 , Jacobus F. A. Jansen 4 , and Walter H Backes 4

1 Philips India Ltd., Bangalore, Karnataka, India, 2 Dept of Neurology, Maastricht University Medical Center, Maastricht, Netherlands, 3 Epilepsy Center Kempenhaeghe, Heeze, Netherlands, 4 Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands

Temporal heterogeneity in BOLD time-series in patients with a suspect of a single epileptic seizure (first-fit) has been compared to patients with new-onset epilepsy and healthy controls. Known temporal heterogeneity measures, including fractional amplitude of low frequency fluctuations and regional homogeneity, were used for time-series analysis. Results suggest that particularly for the low frequency range, 0.02-0.09 Hz, first-fit patients show decreased amplitude of the BOLD fluctuations. These effects show that the analysis of frequency fluctuations has potential to predict which patients are at increased risk to develop epilepsy after a single seizure.

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