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Abstract #2081

The Relationship between Level of Consciousness and Variability of Brain Connectivity

Christina Hamilton 1 , Yuncong Ma 1 , and Pablo Perez 1

1 Pennsylvania State University, State College, PA, United States

Anesthesia is an altered state of consciousness that can be characterized by a complex interaction between an individuals level of arousal and awareness. Resting-state functional magnetic resonance imaging (rsfMRI) has been shown to be a useful tool for investigating systems-level changes in functional brain connectivity during anesthesia-induced unconsciousness (AIU). Here we use rsfMRI and behavioral measures of anesthetic depth to investigate the dose-dependent effect of isoflurane on functional brain connectivity. These findings provide insight into the relationship between neuroimaging data and behavioral measures of anesthetic depth, which may provide us with a better understanding of the neural basis of AIU.

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