Modulation of functional connectivity during finger tapping and resting state in patients with MS

We investigated the modulation of motor connectivity in patients with multiple sclerosis (MS) and controls by acquiring fc in 3 conditions (rest, 2 Hz paced finger tapping and self-paced complex finger tapping).Significant fc changes in some brain regions during 2 motor tasks from rs were exhibited, showing fc network can be modulated under different states in controls and patients with MS. There was decreased fc in certain regions of patient compared with controls. The observation that more group differences were observed in the resting state suggests that this may be the most effective way of studying functional impairment in MS.

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