Meeting Banner
Abstract #2084

Increased variability across time accounts for reduced connectivity within the default mode network in autism: a dynamic fcMRI study

Maryam Falahpour 1 , Wesley K. Thompson 2 , Angela E. Abbott 3 , Mark E. Mulvey 3 , Michael Datko 3 , Ralph-Axel Mller 3 , and Thomas T. Liu 1

1 Center for Functional MRI, University of California San Diego, La Jolla, CA, United States, 2 Department of Psychiatry, University of California San Diego, La Jolla, CA, United States, 3 Brain Development Imaging Lab, Department of Psychology, San Diego State University, CA, United States

fMRI resting state studies of subjects with autism spectrum disorder (ASD) have revealed altered functional connectivity (FC) in the default mode network (DMN), as compared to typically developed subjects. We hypothesized that the group differences in FC might reflect differences in the temporal variability of the FC measures. We used mediation analysis to examine the relation between FC and the temporal variability in FC between the two major nodes of the DMN, the posterior cingulate cortex and the medial prefrontal cortex. Our results suggest that under-connectivity in ASD population may be in part due to higher temporal variability in FC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here