Abstract #2084
Increased variability across time accounts for reduced connectivity within the default mode network in autism: a dynamic fcMRI study
Maryam Falahpour 1 , Wesley K. Thompson 2 , Angela E. Abbott 3 , Mark E. Mulvey 3 , Michael Datko 3 , Ralph-Axel Mller 3 , and Thomas T. Liu 1
1
Center for Functional MRI, University of
California San Diego, La Jolla, CA, United States,
2
Department
of Psychiatry, University of California San Diego, La
Jolla, CA, United States,
3
Brain Development
Imaging Lab, Department of Psychology, San Diego State
University, CA, United States
fMRI resting state studies of subjects with autism
spectrum disorder (ASD) have revealed altered functional
connectivity (FC) in the default mode network (DMN), as
compared to typically developed subjects. We
hypothesized that the group differences in FC might
reflect differences in the temporal variability of the
FC measures. We used mediation analysis to examine the
relation between FC and the temporal variability in FC
between the two major nodes of the DMN, the posterior
cingulate cortex and the medial prefrontal cortex. Our
results suggest that under-connectivity in ASD
population may be in part due to higher temporal
variability in FC.
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