Abstract #2085
Validation of in vivo structural template of human brainstem nuclei by fMRI at 7 Tesla
Marta Bianciardi 1 , Nicola Toschi 1,2 , Cornelius Eichner 1 , Kawin Setsompop 1 , Jonathan R. Polimeni 1 , Bruce R. Rosen 1 , and Lawrence L. Wald 1
1
Department of Radiology, A.A. Martinos
Center for Biomedical Imaging, MGH and Harvard Medical
School, Boston, MA, United States,
2
Medical
Physics Section, Department of Biomedicine and
Prevention, Faculty of Medicine, University of Rome Tor
Vergata, Rome, Italy
The aim of this work was to validate our recently
developed in-vivo structural template of human
brainstem-nuclei (Bn) of the ascending-arousal,
autonomic and motor systems by 1.1mm-isotropic fMRI at
7Tesla. For each of the 18 Bn-labels of the structural
template, a spatially matched functional parcel in the
brainstem was identified by ICA. Our results also showed
that structural Bn-labels were functionally connected to
specific brain regions as expected from previous work.
This work provides a preliminary validation of the
in-vivo structural Bn template, which is a key step
towards its use in future studies of human brainstem
function and pathology.
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