Abstract #2090
Neural activity associated with spontaneous eye opening and closure in the awake macaque
Catie Chang 1 , David A Leopold 2 , Hendrik Mandelkow 1 , Marieke L Schlvinck 3 , and Jeff H Duyn 1
1
Advanced MRI Section, Laboratory of
Functional and Molecular Imaging, NINDS, NIH, Bethesda,
MD, United States,
2
Section
on Cognitive Neurophysiology and Imaging, Laboratory of
Neuropsychology, NIMH, NIH, Bethesda, MD, United States,
3
Ernst
Strüngmann Institute (ESI) for Neuroscience in
Cooperation with Max Planck Society, Frankfurt am Main,
Germany
Here, we investigated the spatial and temporal
relationship between neural activity and a behavioral
index of vigilance state (spontaneous eye open/closure
in darkness) using simultaneous fMRI and
electrophysiological data from unanesthetized macaques
in the resting state. We observed a robust relationship
between resting-state electrophysiological and fMRI
signals and our measure of eye open/closure, with eye
opening correlated with decreases in fMRI signal across
most of the cortex, and with increases in the thalamus
and cerebellum. Temporal analysis indicated that
thalamic and cerebellar regions exhibited increases in
signal that preceded the signal decreases in cortex.
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