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Abstract #2090

Neural activity associated with spontaneous eye opening and closure in the awake macaque

Catie Chang 1 , David A Leopold 2 , Hendrik Mandelkow 1 , Marieke L Schlvinck 3 , and Jeff H Duyn 1

1 Advanced MRI Section, Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD, United States, 2 Section on Cognitive Neurophysiology and Imaging, Laboratory of Neuropsychology, NIMH, NIH, Bethesda, MD, United States, 3 Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main, Germany

Here, we investigated the spatial and temporal relationship between neural activity and a behavioral index of vigilance state (spontaneous eye open/closure in darkness) using simultaneous fMRI and electrophysiological data from unanesthetized macaques in the resting state. We observed a robust relationship between resting-state electrophysiological and fMRI signals and our measure of eye open/closure, with eye opening correlated with decreases in fMRI signal across most of the cortex, and with increases in the thalamus and cerebellum. Temporal analysis indicated that thalamic and cerebellar regions exhibited increases in signal that preceded the signal decreases in cortex.

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